/* THEME VARIABLES */
:root {
    --primary-color: #6487ff;
    --primary-accent: #90a8ff;
    --secondary-color: #3e55d1;
    --accent-color: #6fd9ff;
    --accent-glow: 174 216 255;
    --bg-0: #05070b;
    --bg-1: #0e141b;
    --bg-2: #18222d;
    --bg-3: #21303d;
    --border-color: #2f4152;
    --text-color: #f1f5f9;
    --text-dim: #b2c1d3;
    --danger-color: #ff4d84;
    --warning-color: #f39c12;
    --success-color: #2ecc71;
    --focus-ring: 0 0 0 3px rgba(var(--accent-glow)/0.45);
    --border-radius: 12px;
    --box-shadow: 0 4px 18px -4px rgba(0, 0, 0, .6), 0 0 0 1px rgba(255, 255, 255, .04);
    --transition: 120ms cubic-bezier(.4, 0, .2, 1);
    --gradient-accent: linear-gradient(135deg, #688fff, #8a55ff 55%, #31c6ff);
    --font-stack: 'Segoe UI', Tahoma, Geneva, Verdana, sans-serif;
}

[data-theme="light"] {
    --primary-color: #445eea;
    --primary-accent: #2f4bd6;
    --secondary-color: #2d52c9;
    --accent-color: #0d74d7;
    --accent-glow: 13 116 215;
    --bg-0: #f4f7fb;
    --bg-1: #ffffff;
    --bg-2: #f0f3f8;
    --bg-3: #e2e8f0;
    --border-color: #d0d9e4;
    --text-color: #1d242d;
    --text-dim: #5b6977;
    --danger-color: #d81f60;
    --warning-color: #c77800;
    --success-color: #218d53;
    --focus-ring: 0 0 0 3px rgba(13, 116, 215, .35);
    --box-shadow: 0 2px 6px rgba(0, 0, 0, .08), 0 0 0 1px rgba(0, 0, 0, .04);
    --gradient-accent: linear-gradient(135deg, #4e6bff, #8f37ff 60%, #0d74d7)
}

[data-theme="light"] body {
    background: radial-gradient(circle at 20% 15%, rgba(78, 107, 255, .15), transparent 60%), radial-gradient(circle at 80% 70%, rgba(13, 116, 215, .12), transparent 60%), var(--bg-0)
}

[data-theme="light"] .search-container,
[data-theme="light"] .results-container {
    backdrop-filter: blur(4px)
}

[data-theme="light"] .search-box input,
[data-theme="light"] .filter-group select,
[data-theme="light"] .select2-container--default .select2-selection--single {
    background: var(--bg-2);
    border-color: var(--border-color);
    color: var(--text-color)
}

[data-theme="light"] .search-container {
    background: linear-gradient(145deg, #ffffff, #edf2f7 65%);
    border: 1px solid var(--border-color);
    box-shadow: 0 4px 20px -4px rgba(0, 0, 0, .12), 0 0 0 1px rgba(0, 0, 0, .04)
}

[data-theme="light"] .results-container {
    background: linear-gradient(150deg, #ffffff, #f2f6fa);
    border: 1px solid var(--border-color);
    box-shadow: 0 4px 22px -4px rgba(0, 0, 0, .12), 0 0 0 1px rgba(0, 0, 0, .04)
}

[data-theme="light"] .filter-group select:disabled {
    background: var(--bg-3);
    color: var(--text-dim);
    opacity: .8
}

[data-theme="light"] .metric-value {
    background: linear-gradient(135deg, rgba(78, 107, 255, .12), rgba(13, 116, 215, .08));
    border-color: var(--border-color)
}

[data-theme="light"] .mouse-count {
    background: linear-gradient(120deg, rgba(78, 107, 255, .15), rgba(13, 116, 215, .15));
    border-color: var(--border-color);
    box-shadow: none;
    color: var(--primary-color)
}

[data-theme="light"] .info-box {
    background: var(--bg-1);
    border-color: var(--border-color);
    box-shadow: 0 10px 30px -6px rgba(0, 0, 0, .12)
}

[data-theme="light"] .result-item {
    background: linear-gradient(150deg, #ffffff, #f2f5fa);
    box-shadow: 0 2px 8px rgba(0, 0, 0, .07), 0 0 0 1px rgba(0, 0, 0, .04)
}

[data-theme="light"] .result-item:hover {
    box-shadow: 0 6px 18px -4px rgba(0, 0, 0, .18), 0 0 0 1px rgba(78, 107, 255, .4)
}

[data-theme="light"] .meta-label {
    color: var(--text-dim)
}

[data-theme="light"] .gene-description {
    color: #435160
}

[data-theme="light"] .link-icon {
    color: var(--primary-color)
}

[data-theme="light"] .select2-dropdown {
    background: var(--bg-1);
    border-color: var(--border-color);
    box-shadow: 0 10px 28px -6px rgba(0, 0, 0, .18)
}

[data-theme="light"] .select2-results__option--highlighted {
    background: var(--primary-color)
}

[data-theme="light"] footer {
    background: var(--bg-2)
}

.external-links .ext-link.theme-toggle {
    cursor: pointer;
    min-width: 0;
    padding: .55rem .8rem;
    display: flex;
    align-items: center;
    gap: .4rem;
    background: linear-gradient(145deg, #344050, #262f38);
    border: 1px solid var(--border-color)
}

[data-theme="light"] .external-links .ext-link.theme-toggle {
    background: linear-gradient(145deg, #edf2f7, #dfe6ef)
}

.external-links .ext-link.theme-toggle .theme-label {
    font-weight: 600;
    font-size: .7rem;
    letter-spacing: .6px
}

* {
    margin: 0;
    padding: 0;
    box-sizing: border-box
}

html {
    font-size: 16px
}

body {
    font-family: var(--font-stack);
    line-height: 1.6;
    color: var(--text-color);
    background: radial-gradient(circle at 20% 15%, rgba(104, 143, 255, .18), transparent 55%), radial-gradient(circle at 78% 72%, rgba(49, 198, 255, .15), transparent 60%), var(--bg-0);
    min-height: 100vh;
    display: flex;
    flex-direction: column;
    -webkit-font-smoothing: antialiased
}

.container {
    max-width: 1440px;
    margin: 0 auto;
    padding: clamp(1rem, 2vw, 2.25rem);
    flex: 1;
    width: 100%
}

header.site-header {
    text-align: center;
    margin-bottom: 1.75rem
}

header.site-header h1 {
    font-size: clamp(2rem, 4.2vw, 2.85rem);
    background: var(--gradient-accent);
    -webkit-background-clip: text;
    background-clip: text;
    color: transparent;
    font-weight: 700;
    letter-spacing: .5px;
    margin: 0 0 .4rem
}

header.site-header p {
    font-size: 1.1rem;
    color: var(--text-dim);
    font-weight: 400
}

.top-right-links {
    position: absolute;
    top: 14px;
    right: 24px;
    z-index: 80;
    display: flex;
    gap: .85rem
}

.external-links {
    display: flex;
    gap: .85rem;
    flex-wrap: wrap;
    margin-top: .75rem
}

.external-links .ext-link {
    --bg: linear-gradient(145deg, #2a3845, #1b242d);
    display: inline-flex;
    align-items: center;
    gap: .5rem;
    padding: .55rem .95rem;
    border: 1px solid var(--border-color);
    border-radius: 10px;
    text-decoration: none;
    font-size: .8rem;
    font-weight: 500;
    letter-spacing: .3px;
    background: var(--bg);
    color: var(--text-color);
    position: relative;
    overflow: hidden;
    transition: var(--transition);
    box-shadow: 0 2px 6px -1px rgba(0, 0, 0, .55), 0 0 0 1px rgba(255, 255, 255, .05)
}

[data-theme="light"] .external-links .ext-link {
    --bg: linear-gradient(145deg, #f1f5fa, #e2e8f0);
    color: var(--primary-accent);
    box-shadow: 0 2px 4px rgba(0, 0, 0, .08), 0 0 0 1px rgba(0, 0, 0, .06)
}

[data-theme="light"] .external-links .ext-link:hover {
    box-shadow: 0 6px 14px -4px rgba(0, 0, 0, .18), 0 0 0 1px rgba(68, 94, 234, .35)
}

.external-links .ext-link:before {
    content: "";
    position: absolute;
    inset: 0;
    opacity: 0;
    background: linear-gradient(120deg, rgba(104, 143, 255, .35), rgba(49, 198, 255, .35));
    transition: var(--transition)
}

.external-links .ext-link:hover:before {
    opacity: 1
}

.external-links .ext-link:hover {
    transform: translateY(-2px);
    box-shadow: 0 6px 18px -4px rgba(0, 0, 0, .75), 0 0 0 1px rgba(111, 217, 255, .35)
}

.external-links .ext-link.github {
    --bg: linear-gradient(145deg, #2d3b48, #1d262f)
}

[data-theme="light"] .external-links .ext-link.github {
    --bg: linear-gradient(145deg, #e8eef5, #d8e1ea)
}

.external-links .ext-link.biorxiv {
    --bg: linear-gradient(145deg, #5b1844, #3a142f)
}

[data-theme="light"] .external-links .ext-link.biorxiv {
    --bg: linear-gradient(145deg, #ffe3f3, #f6d0ea);
}

@media (max-width:700px) {
    .top-right-links {
        position: static;
        justify-content: center;
        margin-top: .75rem
    }
}

.search-container {
    background: linear-gradient(155deg, rgba(24, 34, 45, .94), rgba(14, 20, 27, .92));
    backdrop-filter: blur(10px);
    border: 1px solid rgba(255, 255, 255, .06);
    border-radius: var(--border-radius);
    box-shadow: var(--box-shadow);
    padding: 1.6rem clamp(1.3rem, 1.8vw, 2rem) 1.8rem;
    margin: 0 auto 2.2rem;
    width: 100%;
    max-width: 1400px;
    position: relative;
    overflow: visible;
    z-index: 500
}

.search-box {
    display: flex;
    margin-bottom: 1rem;
    width: 100%
}

.search-box input {
    flex: 1;
    padding: .85rem 1.1rem;
    border: 1px solid var(--border-color);
    background: var(--bg-2);
    color: var(--text-color);
    border-radius: var(--border-radius) 0 0 var(--border-radius);
    font-size: .95rem;
    transition: var(--transition);
    min-width: 300px
}

.search-box input::placeholder {
    color: var(--text-dim)
}

.search-box input:focus {
    outline: none;
    border-color: var(--primary-color);
    box-shadow: var(--focus-ring)
}

.search-box button {
    padding: 0 1.55rem;
    background: var(--gradient-accent);
    color: #fff;
    font-weight: 600;
    letter-spacing: .5px;
    border: 1px solid var(--secondary-color);
    border-radius: 0 var(--border-radius) var(--border-radius) 0;
    cursor: pointer;
    display: flex;
    align-items: center;
    justify-content: center;
    gap: .5rem;
    position: relative;
    overflow: hidden;
    transition: var(--transition)
}

[data-theme="light"] .search-box button {
    border-color: var(--primary-accent)
}

.search-box button:before {
    content: "";
    position: absolute;
    inset: 0;
    background: linear-gradient(120deg, rgba(255, 255, 255, .18), transparent 55%);
    opacity: 0;
    transition: var(--transition)
}

.search-box button:hover:before {
    opacity: 1
}

.search-box button:hover {
    filter: brightness(1.18)
}

.filter-row {
    display: flex;
    gap: 15px;
    margin-top: 15px;
    flex-wrap: wrap
}

.filter-group {
    display: flex;
    align-items: center;
    gap: 8px;
    position: relative
}

.filter-group label {
    font-size: .9rem;
    letter-spacing: .3px;
    font-weight: 600;
    color: var(--text-dim);
    text-transform: none
}

.filter-group select {
    padding: .55rem 2rem .55rem .85rem;
    border: 1px solid #395064;
    border-radius: 10px;
    font-size: .9rem;
    background: linear-gradient(145deg, #1d2733, #141b23);
    color: var(--text-color);
    min-width: 150px;
    transition: var(--transition);
    line-height: 1.2;
    height: 40px;
    appearance: none;
    -webkit-appearance: none;
    font-weight: 500;
    box-shadow: 0 0 0 1px rgba(255, 255, 255, .05), 0 4px 10px -2px rgba(0, 0, 0, .5);
    position: relative
}

/* Unified style for metric and sort order selects to match custom structure trigger */
select.styled-select {
    background: linear-gradient(145deg, #1d2733, #141b23);
    border: 1px solid #395064;
    box-shadow: 0 0 0 1px rgba(255,255,255,.05), 0 4px 10px -2px rgba(0,0,0,.5);
    font-weight: 500;
}
select.styled-select:focus {
    outline: none;
    border-color: var(--primary-color);
    box-shadow: 0 0 0 1px var(--primary-color), var(--focus-ring);
}
[data-theme="light"] select.styled-select {
    background: var(--bg-2);
    border: 1px solid var(--border-color);
    box-shadow: none;
}
[data-theme="light"] select.styled-select:focus {
    box-shadow: 0 0 0 1px var(--primary-color), var(--focus-ring);
}

/* Structure select styled via Select2: narrow trigger, wider dropdown */
#structureSelect {
    min-width: 200px
}

/* Custom structure select */
.structure-select-wrapper {
    position: relative;
    display: inline-block;
    font-size: .9rem
}

.structure-select-trigger {
    background: linear-gradient(145deg, #1d2733, #141b23);
    color: var(--text-color);
    border: 1px solid #395064;
    border-radius: 10px;
    height: 40px;
    min-width: 240px;
    padding: 0 .85rem;
    display: flex;
    align-items: center;
    justify-content: flex-start;
    gap: .5rem;
    font-weight: 500;
    cursor: pointer;
    transition: var(--transition);
    box-shadow: 0 0 0 1px rgba(255, 255, 255, .05), 0 4px 10px -2px rgba(0, 0, 0, .5);
    text-align: left;
    position: relative
}

/* Mini variant used in multi-region rows */
.structure-select-wrapper.mini .structure-select-trigger { min-width: 240px; }

.structure-select-trigger.disabled {
    background: var(--bg-3);
    color: #6c7785;
    cursor: not-allowed;
    opacity: .6;
    border-color: var(--border-color);
    box-shadow: none;
}

.structure-select-trigger.disabled:hover {
    border-color: var(--border-color);
}

/* Generic disabled tooltip styling */
.has-disabled-tooltip {
    position: relative;
}

.has-disabled-tooltip[data-disabled-tooltip]:hover:after {
    content: attr(data-disabled-tooltip);
    position: absolute;
    left: 0;
    top: calc(100% + 4px);
    background: var(--bg-2);
    color: var(--text-color);
    border: 1px solid var(--border-color);
    font-size: .7rem;
    padding: .4rem .55rem;
    border-radius: 6px;
    white-space: nowrap;
    box-shadow: 0 6px 18px -6px rgba(0,0,0,.5);
    z-index: 1500;
    pointer-events: none;
}

[data-theme="light"] .has-disabled-tooltip[data-disabled-tooltip]:hover:after {
    background: var(--bg-1);
}

.structure-select-trigger:after {
    content: '\25BE';
    position: absolute;
    right: 14px;
    font-size: .65rem;
    color: var(--text-dim);
    pointer-events: none
}

.structure-select-trigger:hover {
    border-color: var(--primary-color);
}

.structure-select-wrapper.open .structure-select-trigger {
    border-color: var(--primary-color);
    box-shadow: 0 0 0 1px var(--primary-color), var(--focus-ring)
}

.structure-select-panel {
    position: absolute;
    top: calc(100% + 4px);
    left: 0;
    z-index: 1200;
    background: var(--bg-2);
    border: 1px solid var(--border-color);
    border-radius: 12px;
    box-shadow: 0 18px 42px -10px rgba(0, 0, 0, .85), 0 0 0 1px rgba(255, 255, 255, .05);
    width: 460px;
    max-width: 640px;
    display: none;
    padding: .6rem .65rem .75rem
}

.structure-select-wrapper.open .structure-select-panel {
    display: block;
    animation: fadeIn .14s ease
}

@keyframes fadeIn {
    from {
        opacity: 0;
        transform: translateY(-4px)
    }

    to {
        opacity: 1;
        transform: translateY(0)
    }
}

.structure-select-searchwrap {
    margin-bottom: .55rem
}

.structure-select-search {
    width: 100%;
    padding: .55rem .7rem;
    border: 1px solid var(--border-color);
    border-radius: 8px;
    background: var(--bg-1);
    color: var(--text-color);
    font-size: .85rem
}

.structure-select-search:focus {
    outline: none;
    border-color: var(--primary-color);
    box-shadow: var(--focus-ring)
}

.structure-select-options {
    list-style: none;
    max-height: 400px;
    overflow-y: auto;
    margin: 0;
    padding: 0;
    scrollbar-width: thin
}

.structure-select-options::-webkit-scrollbar {
    width: 8px
}

.structure-select-options::-webkit-scrollbar-track {
    background: var(--bg-1)
}

.structure-select-options::-webkit-scrollbar-thumb {
    background: var(--bg-3);
    border-radius: 4px
}

.structure-option {
    padding: .5rem .7rem;
    border-radius: 6px;
    font-size: .85rem;
    cursor: pointer;
    display: flex;
    align-items: center;
    color: var(--text-color);
    line-height: 1.2
}

/* Hover / keyboard focus highlight */
.structure-option:hover,
.structure-option.focused {
    background: var(--primary-color);
    color: #fff;
}
/* Selected state (when not currently hovered or focused) */
.structure-option.selected {
    background: linear-gradient(120deg, var(--primary-color), var(--secondary-color));
    color: #fff;
    font-weight: 600;
}
/* Remove duplicate blue bars: if selected item is hovered or focused, show only the hover/focus style (override gradient) */
.structure-option.selected.hovering,
.structure-option.selected.focused { /* class 'hovering' will be added via JS if needed */
    background: var(--primary-color);
    font-weight: 600;
}

[data-theme="light"] .structure-select-trigger {
    background: var(--bg-2);
    border: 1px solid var(--border-color);
    box-shadow: none;
    color: var(--text-color)
}

[data-theme="light"] .structure-select-panel {
    background: var(--bg-1);
    box-shadow: 0 8px 24px -6px rgba(0, 0, 0, .18)
}

[data-theme="light"] .structure-select-search {
    background: var(--bg-2)
}

[data-theme="light"] .structure-option {
    color: var(--text-color)
}

[data-theme="light"] .structure-option:hover,
[data-theme="light"] .structure-option.focused {
    background: var(--primary-color);
    color: #fff;
}

[data-theme="dark"] .select2-dropdown {
    background: var(--bg-2);
    border: 1px solid var(--border-color);
    color: var(--text-color);
    box-shadow: 0 10px 28px -6px rgba(0, 0, 0, .75)
}

[data-theme="dark"] .select2-dropdown .select2-results__option {
    color: var(--text-color);
    font-size: .85rem
}

[data-theme="dark"] .select2-results__option--highlighted {
    background: var(--primary-color) !important;
    color: #fff !important
}

[data-theme="dark"] .select2-container--default .select2-selection--single {
    background: linear-gradient(145deg, #1d2733, #141b23);
    border: 1px solid #395064;
    box-shadow: 0 0 0 1px rgba(255, 255, 255, .05)
}

[data-theme="dark"] .select2-container--default .select2-selection--single .select2-selection__rendered {
    color: var(--text-color);
    font-size: .9rem;
    line-height: 40px;
    padding-left: 12px
}

[data-theme="dark"] .select2-container--default .select2-selection--single:focus {
    outline: 0;
    border-color: var(--primary-color);
    box-shadow: var(--focus-ring)
}

[data-theme="dark"] .select2-search--dropdown .select2-search__field {
    background: var(--bg-1);
    border: 1px solid var(--border-color);
    color: var(--text-color);
    padding: .45rem .55rem;
    border-radius: 6px;
    font-size: .85rem
}

[data-theme="dark"] .select2-search--dropdown .select2-search__field:focus {
    outline: none;
    border-color: var(--primary-color);
    box-shadow: var(--focus-ring)
}

.filter-group:after {
    content: '\25BE';
    position: absolute;
    right: 14px;
    top: 50%;
    transform: translateY(-50%);
    pointer-events: none;
    font-size: .7rem;
    color: var(--text-dim);
    opacity: .9
}

[data-theme="light"] .filter-group {
    color: var(--text-color)
}

[data-theme="light"] .filter-group select {
    border: 1px solid var(--border-color);
    box-shadow: none;
    background: var(--bg-2)
}

[data-theme="light"] .filter-group:after {
    color: var(--text-dim)
}

.filter-group select:focus {
    outline: none;
    border-color: var(--primary-color);
    box-shadow: 0 0 0 1px var(--primary-color), var(--focus-ring)
}

.filter-group select option {
    background: var(--bg-2);
    color: var(--text-color)
}

.results-container {
    background: linear-gradient(165deg, rgba(26, 36, 47, .9), rgba(16, 23, 30, .94));
    backdrop-filter: blur(10px);
    border: 1px solid rgba(255, 255, 255, .07);
    border-radius: var(--border-radius);
    box-shadow: var(--box-shadow);
    padding: 1.4rem 2rem 2.2rem;
    max-width: 1400px;
    width: 100%;
    margin: 0 auto;
    min-height: 300px;
    position: relative;
    overflow: hidden
}

#resultsList {
    list-style: none;
    display: grid;
    gap: 15px;
    padding: 10px 0;
    position: relative;
    z-index: 1
}

.result-item {
    width: 100%;
    min-width: 100%;
    margin-bottom: 15px;
    border-radius: 18px;
    background: linear-gradient(150deg, #1f2a36, #141c24 65%);
    box-shadow: 0 2px 10px -2px rgba(0, 0, 0, .7), 0 0 0 1px rgba(255, 255, 255, .05);
    transition: var(--transition);
    overflow: hidden;
    min-height: 140px;
    position: relative
}

.result-item:hover {
    transform: translateY(-4px);
    box-shadow: 0 6px 26px -6px rgba(0, 0, 0, .85), 0 0 0 1px rgba(104, 143, 255, .35)
}

.result-link {
    display: block;
    padding: 26px 28px 28px;
    text-decoration: none;
    color: var(--text-color);
    position: relative;
    z-index: 1
}

.result-header {
    display: grid;
    grid-template-columns: auto 1fr auto auto;
    align-items: center;
    margin-bottom: 8px;
    gap: 15px;
    min-height: 60px
}

.result-header i {
    margin-right: 12px;
    color: var(--accent-color);
    font-size: 1.15em
}

.link-icon {
    color: var(--accent-color);
    opacity: .75;
    margin-left: auto
}

.result-link:hover .link-icon {
    opacity: 1
}

.result-title {
    min-width: 300px;
    max-width: 600px
}

.gene-name {
    font-size: 1.3em;
    color: var(--primary-color);
    margin-bottom: .3em;
    font-weight: 600;
    letter-spacing: .4px;
    transition: var(--transition)
}

.result-link:hover .gene-name {
    color: var(--accent-color);
    text-shadow: 0 0 6px rgba(var(--accent-glow)/0.55)
}

.gene-description {
    color: #c4d2df;
    font-size: 1rem;
    line-height: 1.6;
    margin-bottom: 12px;
    max-width: 900px
}

.gene-meta {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
    gap: 12px;
    margin-top: 15px;
    padding-top: 15px;
    border-top: 1px solid #2f4152;
    min-height: 40px
}

.meta-label {
    font-weight: 600;
    color: var(--text-dim);
    margin-right: 8px;
    min-width: 90px;
    font-size: .9rem;
    letter-spacing: .3px;
    text-transform: none
}

.meta-value {
    color: var(--text-color);
    font-size: .9rem;
    font-weight: 500
}

.metric-values {
    display: grid;
    grid-template-columns: repeat(4, 1fr);
    gap: 1.5rem;
    width: 100%;
    min-width: 600px;
    visibility: hidden;
    height: 0;
    transition: var(--transition);
    position: relative
}

.show-metrics .metric-values {
    visibility: visible;
    height: auto;
    margin: 15px 0
}

.metric-value {
    display: flex;
    flex-direction: column;
    min-width: 140px;
    padding: 6px 12px;
    background: linear-gradient(135deg, rgba(104, 143, 255, .18), rgba(111, 217, 255, .1));
    border: 1px solid rgba(255, 255, 255, .08);
    border-radius: 14px;
    position: relative
}

.metric-label {
    font-size: .8rem;
    font-weight: 600;
    letter-spacing: .4px;
    color: var(--text-dim);
    text-transform: none;
    margin-bottom: .25rem
}

.metric-number {
    font-weight: 600;
    font-size: 1rem;
    color: var(--accent-color)
}

.mouse-count {
    display: flex;
    align-items: center;
    color: var(--accent-color);
    background: linear-gradient(120deg, rgba(111, 217, 255, .16), rgba(104, 143, 255, .18));
    padding: 6px 14px;
    border-radius: 999px;
    font-size: .9rem;
    min-width: 120px;
    justify-content: center;
    font-weight: 600;
    letter-spacing: .3px;
    border: 1px solid rgba(255, 255, 255, .1);
    box-shadow: 0 0 0 1px rgba(104, 143, 255, .25);
    margin-left: auto
}

.metrics-info {
    margin-top: 1rem;
    position: relative
}

.info-button {
    background: none;
    border: none;
    color: var(--accent-color);
    cursor: pointer;
    font-size: .9rem;
    padding: .5rem;
    font-weight: 600;
    letter-spacing: .3px;
    transition: var(--transition)
}

.info-button:hover {
    color: var(--primary-color)
}

.info-box {
    background: var(--bg-2);
    border-radius: var(--border-radius);
    box-shadow: 0 4px 24px -4px rgba(0, 0, 0, .75), 0 0 0 1px rgba(255, 255, 255, .05);
    margin-top: .5rem;
    padding: 1.1rem 1.2rem 1.3rem;
    display: none;
    border: 1px solid var(--border-color);
    position: relative
}

.info-box h4 {
    margin-bottom: .55rem;
    color: var(--accent-color);
    letter-spacing: .5px;
    font-weight: 600
}

.info-box ul {
    padding-left: 1.5rem
}

.info-box li {
    margin-bottom: .5rem;
    color: var(--text-dim);
    font-size: .9rem;
    line-height: 1.5
}

#loadingIndicator {
    position: absolute;
    inset: 0;
    background: rgba(14, 20, 27, .95);
    z-index: 10;
    display: flex;
    flex-direction: column;
    align-items: center;
    justify-content: center;
    text-align: center;
    transition: opacity .3s ease;
    border-radius: inherit;
    backdrop-filter: blur(4px)
}
[data-theme="light"] #loadingIndicator {
    background: linear-gradient(180deg, rgba(255, 255, 255, .96), rgba(244, 247, 251, .94));
}

.spinner {
    width: 46px;
    height: 46px;
    border: 4px solid rgba(255, 255, 255, .09);
    border-radius: 50%;
    border-top-color: var(--accent-color);
    border-right-color: var(--primary-color);
    animation: spin .9s linear infinite;
    margin-bottom: 1rem
}
[data-theme="light"] .spinner {
    border: 4px solid rgba(0, 0, 0, .08);
    border-top-color: var(--primary-color);
    border-right-color: var(--accent-color);
    }

@keyframes spin {
    to {
        transform: rotate(360deg)
    }
}

.pagination {
    display: flex;
    justify-content: center;
    align-items: center;
    margin-top: 2rem;
    padding: 1rem 0;
    border-top: 1px solid var(--border-color)
}

.pagination button {
    background: var(--gradient-accent);
    color: #fff;
    border: none;
    border-radius: var(--border-radius);
    padding: .6rem 1.15rem;
    margin: 0 .5rem;
    cursor: pointer;
    transition: var(--transition);
    font-weight: 600;
    letter-spacing: .3px;
    position: relative;
    overflow: hidden;
    font-size: .9rem
}

.pagination button:before {
    content: "";
    position: absolute;
    inset: 0;
    background: linear-gradient(120deg, rgba(255, 255, 255, .25), transparent 60%);
    opacity: 0;
    transition: var(--transition)
}

.pagination button:hover:before {
    opacity: 1
}

.pagination button:hover:not(:disabled) {
    filter: brightness(1.18)
}

.pagination button:disabled {
    background: var(--bg-2);
    color: var(--text-dim);
    cursor: not-allowed;
    filter: none;
    border: 1px solid var(--border-color)
}

.page-info {
    margin: 0 1rem;
    font-size: .9rem;
    color: var(--text-dim)
}

footer {
    text-align: center;
    padding: 1.6rem;
    background: var(--bg-1);
    margin-top: 3rem;
    border-top: 1px solid var(--border-color);
    box-shadow: 0 -2px 12px -4px rgba(0, 0, 0, .55)
}

#currentYear {
    font-weight: 600;
    color: var(--text-dim)
}

.error {
    color: var(--danger-color);
    text-align: center;
    font-weight: 600
}

select:disabled,
select[disabled] {
    background-color: var(--bg-3);
    color: #6c7785;
    cursor: not-allowed;
    opacity: .6
}

.disabled {
    color: #6c7785;
    cursor: not-allowed
}

.select2-container--default .select2-selection--single {
    background: linear-gradient(145deg, #1d2733, #141b23);
    border: 1px solid #395064;
    border-radius: 10px;
    height: 42px;
    display: flex;
    align-items: center;
    transition: var(--transition);
    box-shadow: 0 0 0 1px rgba(255, 255, 255, .05), 0 4px 10px -2px rgba(0, 0, 0, .5);
    position: relative;
    padding-right: 34px
}

.select2-container--default .select2-selection--single:after {
    content: '\25BE';
    position: absolute;
    right: 12px;
    top: 50%;
    transform: translateY(-50%);
    font-size: .65rem;
    color: var(--text-dim);
    pointer-events: none
}

[data-theme="light"] .select2-container--default .select2-selection--single {
    background: var(--bg-2);
    border-color: var(--border-color);
    box-shadow: none
}

.select2-container--default .select2-selection--single .select2-selection__rendered {
    color: var(--text-color);
    line-height: 42px;
    padding-left: 14px;
    font-size: .82rem;
    font-weight: 500
}

.select2-container--default .select2-selection--single .select2-selection__arrow {
    display: none
}

.select2-dropdown {
    background: var(--bg-2);
    border: 1px solid #395064;
    box-shadow: 0 10px 30px -6px rgba(0, 0, 0, .85)
}

.select2-results__option {
    padding: 8px 12px;
    font-size: .8rem
}

.select2-results__option--highlighted {
    background: var(--primary-color);
    color: #fff
}

.select2-container--default.select2-container--disabled .select2-selection--single {
    background: var(--bg-3);
    color: #6c7785;
    cursor: not-allowed;
    opacity: .6
}

.select2-container--default.select2-container--disabled .select2-selection--single .select2-selection__arrow {
    opacity: .45
}

.select2-container--disabled .select2-selection--multiple {
    background: var(--bg-3);
    color: #6c7785;
    cursor: not-allowed
}

@media (max-width:1200px) {
    .search-container {
        width: calc(100% - 4rem)
    }

    .metric-values {
        grid-template-columns: repeat(2, 1fr)
    }

    .info-box {
        width: 350px
    }
}

@media (max-width:768px) {
    .container {
        padding: 1rem
    }

    header.site-header h1 {
        font-size: 2.2rem
    }

    .search-box input {
        padding: .65rem
    }

    .search-box button {
        padding: 0 1rem
    }

    .results-container {
        padding: 1.25rem 1.25rem 2rem
    }

    .gene-meta,
    .metric-values {
        grid-template-columns: 1fr
    }

    .filter-row {
        flex-direction: column;
        gap: 10px
    }

    .filter-group {
        width: 100%
    }

    .filter-group select {
        width: 100%
    }

    .info-box {
        position: fixed;
        top: 50%;
        left: 50%;
        transform: translate(-50%, -50%);
        width: 92%;
        max-height: 80vh;
        overflow-y: auto
    }
}

.metric-rank {
    position: absolute;
    top: -8px;
    right: -8px;
    background: var(--gradient-accent);
    color: #fff;
    border-radius: 12px;
    padding: 2px 20px;
    min-width: 24px;
    height: 20px;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: .55rem;
    font-weight: 700;
    box-shadow: 0 2px 6px -1px rgba(0, 0, 0, .65), 0 0 0 1px rgba(255, 255, 255, .1);
    z-index: 1;
    white-space: nowrap;
    letter-spacing: .5px;
    text-transform: uppercase
}

.close-button {
    background: var(--gradient-accent);
    color: #fff;
    border: none;
    border-radius: 12px;
    padding: .65rem 1.2rem;
    margin-top: 1rem;
    cursor: pointer;
    transition: var(--transition);
    display: flex;
    align-items: center;
    justify-content: center;
    gap: .55rem;
    font-size: .9rem;
    font-weight: 600;
    letter-spacing: .3px;
    box-shadow: 0 2px 8px -2px rgba(0, 0, 0, .65), 0 0 0 1px rgba(255, 255, 255, .05)
}

.close-button i {
    font-size: .85em
}

.close-button:hover {
    filter: brightness(1.18);
    transform: translateY(-2px)
}

.close-button:active {
    transform: translateY(0)
}

.visually-hidden {
    position: absolute !important;
    width: 1px !important;
    height: 1px !important;
    padding: 0 !important;
    margin: -1px !important;
    overflow: hidden !important;
    clip: rect(0 0 0 0) !important;
    border: 0 !important
}

/* Multi-region search styles */
.multi-region-inline { display:flex; flex-direction:column; gap:.55rem; }
.region-criteria-inline { display:flex; flex-direction:column; gap:.45rem; }
.region-criterion { display:flex; gap:.4rem; align-items:center; background:transparent; padding:0; border:0; position:relative; }
.region-criterion .crit-label { font-size:.9rem; letter-spacing:.3px; font-weight:600; color:var(--text-dim); }
.region-criterion select { padding:.55rem 2rem .55rem .85rem; border:1px solid #395064; border-radius:10px; font-size:.9rem; background:linear-gradient(145deg,#1d2733,#141b23); color:var(--text-color); min-width:200px; font-weight:500; height:40px; line-height:1.2; box-shadow:0 0 0 1px rgba(255,255,255,.05), 0 4px 10px -2px rgba(0,0,0,.5); }
.region-criterion select option { background: var(--bg-2); color: var(--text-color); -webkit-text-fill-color: var(--text-color); }
[data-theme="light"] .region-criterion select option { background: var(--bg-1); color: var(--text-color); }
.region-criterion .remove-region { background:linear-gradient(145deg,#5a1f2f,#3a121d); border:1px solid #7d2d40; color:#ffb8c9; padding:.55rem .9rem; border-radius:10px; font-size:.75rem; cursor:pointer; display:inline-flex; align-items:center; gap:.45rem; transition:var(--transition); height:40px; font-weight:600; letter-spacing:.4px; }
.region-criterion .remove-region:hover { filter: brightness(1.18); }
.add-region-btn { background:var(--gradient-accent); border:1px solid var(--secondary-color); color:#fff; font-weight:600; letter-spacing:.4px; padding:.55rem .9rem; border-radius:10px; cursor:pointer; display:inline-flex; align-items:center; gap:.45rem; font-size:.75rem; box-shadow:0 2px 6px -2px rgba(0,0,0,.55),0 0 0 1px rgba(255,255,255,.05); transition:var(--transition); height:40px; align-self:flex-start; }
.add-region-btn.small { height:40px; }
.add-region-btn:hover { filter:brightness(1.15); }
.avg-rank-badge { 
    background: linear-gradient(135deg, var(--primary-color), var(--accent-color)); 
    color: #fff; 
    font-size: .65rem; 
    padding: .25rem .6rem; 
    border-radius: 6px; 
    font-weight: 600; 
    letter-spacing: .5px; 
    margin-left: .5rem; 
    display: inline-flex; 
    align-items: center; 
    flex: 0 0 auto; 
    white-space: nowrap;
}
.criterion-rank-badge {
    background: linear-gradient(135deg,#394d60,#263443); 
    color: var(--text-color); 
    font-size: .55rem; 
    padding: .28rem .55rem; 
    border-radius: 6px; 
    font-weight: 600; 
    letter-spacing: .4px; 
    margin-left: .35rem; 
    line-height: 1.15; 
    display: inline-flex;
    align-items: center;
    flex: 0 1 auto;
    max-width: 300px; 
    white-space: normal; 
    word-break: break-word;
 }
[data-theme="light"] .criterion-rank-badge { background: var(--bg-2); }

/* Row container for multi-region badges placed beneath header */
.multi-region-badges { 
    display: flex; 
    flex-wrap: wrap; 
    gap: .35rem; 
    margin: 4px 0 6px; 
}
[data-theme="light"] .criterion-rank-badge { background: var(--bg-2); }
.multi-region-active-hint { 
    font-size: .65rem; 
    color: var(--text-dim); 
    margin-left: .4rem; 
}
[data-theme="light"] .region-criterion select { background:var(--bg-2); border:1px solid var(--border-color); }

@media (max-width: 700px) { .multi-region-inline { flex-direction:column; } .region-criteria-inline { flex-direction:column; } .region-criterion { flex-wrap:wrap; } .region-criterion select { width:100%; min-width:0; } }